Running Wheels Publications

Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise.

Abstract We tested the hypothesis that aging will exacerbate the negative vascular consequences of exposure to a common physiological stressor, i.e., consumption of a “western” (high fat/high sucrose) diet (WD), by inducing superoxide-associated reductions in nitric oxide (NO) bioavailability, and that this would be prevented by voluntary aerobic exercise. Incremental stiffness and endothelium-dependent dilation (EDD) […]

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Training preserves the intestinal cytokine response to acute exercise in older mice.

Abstract Long-term freewheel training in young animals decreases intestinal lymphocyte expression of inflammatory cytokines and apoptotic proteins. Little is known about these responses in older animals. PURPOSE: This study aimed to evaluate the effect of training on intestinal lymphocyte expression of proinflammatory and anti-inflammatory cytokines and proapoptotic and anti-apoptotic proteins after an acute exercise challenge […]

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Estradiol treatment, physical activity, and muscle function in ovarian-senescent mice.

Abstract Estradiol (E(2)) treatment in young adult, ovariectomized mice increases physical activity and reverses deleterious effects on skeletal muscle. Here we test the hypothesis that E(2) treatment improves muscle function and physical activity in aged, ovarian-senescent mice. Plasma E(2) levels and vaginal cytology confirmed ovarian senescence in 20-month-old C57BL/6 mice. Mice were then randomly divided […]

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Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.

Abstract BACKGROUND: Inflammation is associated with Abeta pathology in Alzheimer’s disease (AD) and transgenic AD models. Previously, it has been demonstrated that chronic stimulation of the immune response induces pro-inflammatory cytokines IL-1beta and TNF-alpha which contribute to neurodegeneration. However, recent evidence has shown that inducing the adaptive immune response reduces Abeta pathology and is neuroprotective. […]

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