Running Wheels Publications

Abstract BACKGROUND: Inflammation is associated with Abeta pathology in Alzheimer’s disease (AD) and transgenic AD models. Previously, it has been demonstrated that chronic stimulation of the immune response induces pro-inflammatory cytokines IL-1beta and TNF-alpha which contribute to neurodegeneration. However, recent evidence has shown that inducing the adaptive immune response reduces Abeta pathology and is neuroprotective. […]

Abstract BACKGROUND: Mice are an important animal model in exercise studies on the immune system, cancer, and aging. There is limited research about the training effects of long-term voluntary exercise in this species. PURPOSE : To describe the training effects in mice given long-term aerobic voluntary exercise. METHODS: Female C57BL/6 mice were randomly assigned to […]