Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation

Publication URL: http://www.sciencedirect.com/science/article/pii/S0041008X13002378

Date: May 30, 2013

Authors: Raymond C. Rancourt, Livia A. Veress , Aftab Ahmad , Tara B. Hendry-Hofer , Jacqueline S. Rioux , Rhonda B. Garlick , Carl W. White

… Pulse oximetry. Oxygen saturation was monitored using the MouseOx oximeter (Starr
Life Science, Pittsburgh, PA). The large rat (300 g) sensor collar was used. Three
measurements per time point were taken. Fibrin immunohistochemistry. … Sulfur mustard (SM) inhalation causes airway injury, with enhanced vascular permeability, coagulation, and airway obstruction. The objective of this study was to determine whether recombinant tissue factor pathway inhibitor (TFPI) could inhibit this pathogenic sequence.

Product: MouseOx® Plus Publications

Study Category: Hypoxia & Inhalation Studies