Anesthesia and Surgical Research

Inspiratory Off-Switch Mediated by Optogenetic Activation of Inhibitory Neurons in the preBötzinger Complex In Vivo

Abstract: The role of inhibitory neurons in the respiratory network is a matter of ongoing debate. Conflicting and contradicting results are manifold and the question whether inhibitory neurons are essential for the generation of the respiratory rhythm as such is controversial. Inhibitory neurons are required in pulmonary reflexes for adapting the activity of the central […]

Learn More

A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice

… NY, USA). The hair of the right thigh was clipped and a pulse oximeter (MouseOx®, Starr Life Sciences Corp., Oakmont, PA, USA) probe was placed to monitor pulse rate (PR) and arterial haemoglobin saturation (SpO2). In addition … Background: Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, […]

Learn More

Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse

… The cardio-pulmonary status of the animals, and the depth of anaesthesia, was monitored using an oxymeter (MouseOx ® , STARR Life Sciences). Experiments were alternated between isoflurane and K/X/A anaesthetics. 2.2. Auditory brainstem response. … Isoflurane is a volatile inhaled anaesthetic widely used in animal research, with particular utility for hearing research. Isoflurane has […]

Learn More

Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare

The implementation of imaging technologies has dramatically increased the efficiency of preclinical studies, enabling a powerful, non-invasive and clinically translatable way for monitoring disease progression in real time and testing new therapies. The ability to image live animals is one of the most important advantages of these technologies. However, this also represents an important challenge […]

Learn More

Contribution of microRNA-203 to the isoflurane preconditioning-induced neuroprotection

… Rectal temperature was maintained at 37 °C ± 0.5 °C. Heart rate and pulse oximeter oxygen saturation (SpO 2 ) were measured continuously during anesthesia with a MouseOx™ Pulse Oximeter (Harvard Apparatus, Holliston, MA). … A prior exposure to isoflurane, a common volatile anesthetic, provides neuroprotection (isoflurane preconditioning). To determine the role of microRNAs […]

Learn More

Contact Form