Abstract: The role of inhibitory neurons in the respiratory network is a matter of ongoing debate. Conflicting and contradicting results are manifold and the question whether inhibitory neurons are essential for the generation of the respiratory rhythm as such is controversial. Inhibitory neurons are required in pulmonary reflexes for adapting the activity of the central […]
… NY, USA). The hair of the right thigh was clipped and a pulse oximeter (MouseOx®, Starr Life Sciences Corp., Oakmont, PA, USA) probe was placed to monitor pulse rate (PR) and arterial haemoglobin saturation (SpO2). In addition … Background: Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, […]
… The settings were adjusted to maintain the end tidal CO 2 at ~32 mm Hg. Rectal temperature was maintained at 37°C ±0.5°C. Heart rate and SpO 2 were measured continuously during anesthesia with a MouseOx™ Pulse Oximeter (Harvard Apparatus, Holliston, MA). … Postoperative cognitive decline is a clinical syndrome. Volatile anesthetics are commonly used […]
… The cardio-pulmonary status of the animals, and the depth of anaesthesia, was monitored using an oxymeter (MouseOx ® , STARR Life Sciences). Experiments were alternated between isoflurane and K/X/A anaesthetics. 2.2. Auditory brainstem response. … Isoflurane is a volatile inhaled anaesthetic widely used in animal research, with particular utility for hearing research. Isoflurane has […]
The implementation of imaging technologies has dramatically increased the efficiency of preclinical studies, enabling a powerful, non-invasive and clinically translatable way for monitoring disease progression in real time and testing new therapies. The ability to image live animals is one of the most important advantages of these technologies. However, this also represents an important challenge […]
… Rectal temperature was maintained at 37 °C ± 0.5 °C. Heart rate and pulse oximeter oxygen saturation (SpO 2 ) were measured continuously during anesthesia with a MouseOx™ Pulse Oximeter (Harvard Apparatus, Holliston, MA). … A prior exposure to isoflurane, a common volatile anesthetic, provides neuroprotection (isoflurane preconditioning). To determine the role of microRNAs […]
