Behavioral Studies

The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client proteins. Acute CHIP overexpression provides neuroprotection against neurotoxic mitochondrial stress, glucocorticoids, and accumulation of toxic amyloid fragments, as well as genetic mutations in other E3 ligases, which have been shown to result in familial […]

… These measurements were repeated with air breathing mice. Peripheral oxygen saturation was assessed periodically with a MouseOx pulse oximeter equipped with a neck collar according to manufacturer instructions (STARR Lifesciences.). Video capture and acquisition. … Assessment of locomotion following exposure of animals to noxious or painful stimuli can offer significant insights into underlying mechanisms […]