Abstract Development of pulmonary hypertension is a common and deadly complication of interstitial lung disease. Little is known regarding the cellular and molecular mechanisms that lead to pulmonary hypertension in patients with interstitial lung disease, and effective treatment options are lacking. The purpose of this study was to examine the adenosine 2B receptor (A2BR) as […]
… Data were expressed as mean percent of the baseline value. In addition a MouseOx pulse oximetry device (STARR Life Sciences, Allison Park, PA) was used to measure oxygen saturation (Spo 2 ) and heart rate. Statistics. The … BACKGROUND: Acute hypotension may be implicated in cognitive dysfunction. l-Type calcium channel blockers in the setting […]
… Pulse oximetry: Five consecutive sustained readings for at least 30 seconds were averaged using the MouseOx® system (Starr Life Sciences, Oakmont, Pennsylvania). Primary lung endothelial cells: Mouse lungs were perfused to clear, harvested en bloc, minced …
Abstract Most people with diabetes develop severe complications of the autonomic nervous system; yet, the underlying causes of many diabetic-induced dysautonomias are poorly understood. Here we explore the idea that these dysautonomias results, in part, from a defect in synaptic transmission. To test this idea, we investigated cultured sympathetic neurons and show that hyperglycemia inactivates […]
Blood flow in mice tumor models was measured with Diffuse Correlation Spectroscopy and compared to concurrent physiology monitoring. Positive correlations were (not) found between flow and heart (breath) rate during anesthesia periods.
Abstract The medullary 5-HT system has potent effects on heart rate and breathing in adults. We asked whether this system mitigates the respiratory instability and bradycardias frequently occurring during the neonatal period. 5,7-Dihydroxytryptamine (5,7-DHT) or vehicle was administered to rat pups at postnatal day 2 (P2), and we then compared the magnitude of bradycardias occurring […]