Abstract Ion influx and water imbalance are major causes of injury during ischemia. Knowledge of the instantaneous subcellular structural and functional changes occurring in vivo, both during ischemia and immediately after the onset of reperfusion, have not been well characterized, mainly due to the extremely rapid progression of these events. To better understand the mechanisms […]
Abstract The objective of this study is to develop and compare the efficacy of a modified versus conventional rat model of chronic myocardial ischemia/reperfusion. Sixty Sprague Dawley (SD) rats were randomly divided into two groups, a modified group (mask respiratory support and short-time chest-opening) and a conventional group (tracheal intubation and long-time chest-opening). Operation time, […]
Abstract Age-related skeletal muscle sarcopenia has been extensively studied and smooth muscle sarcopenia has been recently described, but age-related cardiac sarcopenia has not been previously examined. Therefore, we evaluated adult (7.5 ± 0.5 months; n = 27) and senescent (31.8 ± 0.4 months; n = 26) C57BL/6J mice for cardiac sarcopenia using physiological, histological, and […]
Abstract 1- and 2-adrenergic receptors (ARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by 1AR but not 2AR signaling, and chronic stimulation of the two receptors has opposing effects on myocyte apoptosis and cell survival. Differences in the assembly of macromolecular […]
