Hypoxia & Inhalation Studies

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

… sec of hypoxia). Pulse oximetry. Arterial oxygen saturation in conscious, unrestrained mice was measured using a mouse pulse oximeter (MouseOx, Starr Life Sciences). Blood measurements. Blood samples were obtained from the tail vein of mice using … Oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor (HIF) by a set of closely related prolyl hydroxylase domain enzymes […]

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Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation

… Pulse oximetry. Oxygen saturation was monitored using the MouseOx oximeter (Starr Life Science, Pittsburgh, PA). The large rat (300 g) sensor collar was used. Three measurements per time point were taken. Fibrin immunohistochemistry. … Sulfur mustard (SM) inhalation causes airway injury, with enhanced vascular permeability, coagulation, and airway obstruction. The objective of this study […]

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A New Device to Mimic Intermittent Hypoxia in Mice

… Pulse oxygen saturation levels were recorded using an oximeter placed around the animal’s neck. This device integrates a spectrophotometer and a photoplethysmograph (Collar Clip TM , MouseOx® with Software 6.20; Star™ Life Sciences Corp. Oakmont, PEN). … Intermittent hypoxia (hypoxia-reoxygenation) is often associated with cardiovascular morbidity and mortality. We describe a new device which […]

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Tissue Plasminogen Activator Prevents Mortality from Sulfur Mustard Analog–Induced Airway Obstruction Read More: http://www.atsjournals.org/doi/abs/10.1165/rcmb.2012-0177OC

… Noninvasive Oxygen Saturation Measurements MouseOx small animal oximeter (Starr Life Sciences, Oakmont, PA) in unanesthetized rats was used with XL CollarClip Sensor (Fisher Scientific, Pittsburgh, PA). Arterial Blood Gas Measurements … Sulfur mustard (SM) inhalation causes the rare but life-threatening disorder of plastic bronchitis, characterized by bronchial cast formation, resulting in severe airway obstruction […]

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