Lung Cancer

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

Real-time oxygen saturation percentage of arterial hemoglobin was measured by MouseOx (STARR Life Sciences Corp.) according to the manufacturer’s instructions. Serum erythropoietin was assayed using the mouse/rat Quantikine Immunoassay Kit (R&D Systems). … To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted mouse models. Global Et2 knockout mice exhibited severe growth retardation and […]

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ADORA2B and Hyaluronan Modulate Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The development of pulmonary hypertension (PH) in patients with COPD is strongly associated with increased mortality. Chronic inflammation and changes to the lung extracellular matrix (ECM) have been implicated in the pathogenesis of COPD, yet the mechanisms that lead to PH secondary […]

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In vivo evaluation of venular glycocalyx during hemorrhagic shock in rats using intravital microscopy

… Blood was collected into heparinized glass capillary tubes for hematocrit measurement (microhematocrit centrifuge model MB, Needthan HTS, MA). Hemoglobin O 2 saturation (SO 2 ) and respiratory rate (RR) were measured non-invasively (MouseOx, Starr Lifesciences). … Hemorrhage is responsible for a large percentage of trauma‐related deaths but the mechanisms underlying tissue ischemia are complex […]

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