Real-time oxygen saturation percentage of arterial hemoglobin was measured by MouseOx (STARR Life Sciences Corp.) according to the manufacturer’s instructions. Serum erythropoietin was assayed using the mouse/rat Quantikine Immunoassay Kit (R&D Systems). … To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted mouse models. Global Et2 knockout mice exhibited severe growth retardation and […]
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The development of pulmonary hypertension (PH) in patients with COPD is strongly associated with increased mortality. Chronic inflammation and changes to the lung extracellular matrix (ECM) have been implicated in the pathogenesis of COPD, yet the mechanisms that lead to PH secondary […]
… Measurement of SpO 2 and bradycardias. An infrared emitter/sensor was placed around the neck of 4-d-old pups to measure SpO 2 and heart rate (Mouse Ox; Starr Life Sciences). The pup was then placed in a plethysmography chamber to monitor apneas. … Recurrent apneas are important causes of hospitalization and morbidity in newborns. Gestational […]
… Blood was collected into heparinized glass capillary tubes for hematocrit measurement (microhematocrit centrifuge model MB, Needthan HTS, MA). Hemoglobin O 2 saturation (SO 2 ) and respiratory rate (RR) were measured non-invasively (MouseOx, Starr Lifesciences). … Hemorrhage is responsible for a large percentage of trauma‐related deaths but the mechanisms underlying tissue ischemia are complex […]
… and Caf groups (n = 190) were monitored (during 15 min) immediately before gavage and again 30 min after gavage (for another 15 min), to reduce the manipulation stress and obtain a regular respiratory breathing, by means of a non-invasive sensor (MouseOx STARR Life … While neonatal caffeine treatment is commonly used to alleviate […]
… Arterial oxygen levels were continuously monitored via a pulse oximeter (Starr Life Sciences, Inc, Oakmont, PA), and, if necessary, adjustments were made in tracheal catheter position to maintain oxygen levels at or above 95%. … Obesity decreases baroreflex gain (BRG); however, the mechanisms are unknown. We tested the hypothesis that impaired BRG is related […]
