Modern life involves chronic circadian disruption through artificial light and these disruptions are associated with numerous mental and physical health maladies. Because the developing nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian disruption would negatively impact offspring development and adult function. Pregnant mice were subjected to chronic circadian disruption from the […]
… arterial oxygen saturation (SpO 2 ) or heart rate (HR), we combined respiratory recordings using whole body plethysmography and measures of arterial SpO 2 and heart rate with an oximeter designed for small rodents (Mouse-Ox – STARR Life Sciences, Oakmont, PA, USA). … The carotid body is the main peripheral oxygen sensor involved in […]
Alveolar capillary dysplasia (ACD) is a congenital, lethal disorder of the pulmonary vasculature. Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encodes a lipid phosphatase controlling key cellular functions, including stem/progenitor cell proliferation and differentiation; however, the role of PTEN in mesodermal lung cell lineage formation remains unexamined. To determine the role of mesodermal […]
Abstract Aims Endothelin receptor A (ETA) antagonism normalizes fetal growth in several models of rodent fetal growth restriction (FGR). Our aims were to determine the levels of ETA antagonist in maternal and fetal plasma following chronic maternal administration, and to determine its impact on pregnancy outcome, survival and growth of rat pups. Main methods Timed […]
