Neonatal Rodent Studies

Role of ATP and adenosine on carotid body function during development

… arterial oxygen saturation (SpO 2 ) or heart rate (HR), we combined respiratory recordings using whole body plethysmography and measures of arterial SpO 2 and heart rate with an oximeter designed for small rodents (Mouse-Ox – STARR Life Sciences, Oakmont, PA, USA). … The carotid body is the main peripheral oxygen sensor involved in […]

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Mesodermal Pten inactivation leads to alveolar capillary dysplasia-like phenotype

Alveolar capillary dysplasia (ACD) is a congenital, lethal disorder of the pulmonary vasculature. Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encodes a lipid phosphatase controlling key cellular functions, including stem/progenitor cell proliferation and differentiation; however, the role of PTEN in mesodermal lung cell lineage formation remains unexamined. To determine the role of mesodermal […]

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Endothelin receptor antagonist has limited access to the fetal compartment during chronic maternal administration late in pregnancy

Abstract Aims Endothelin receptor A (ETA) antagonism normalizes fetal growth in several models of rodent fetal growth restriction (FGR). Our aims were to determine the levels of ETA antagonist in maternal and fetal plasma following chronic maternal administration, and to determine its impact on pregnancy outcome, survival and growth of rat pups. Main methods Timed […]

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