RSV & Other Acute Respiratory Disorders

Development and evaluation of murine lung-specific disease models for Pseudomonas aeruginosa applicable to therapeutic testing.

Pseudomonas aeruginosa is an opportunistic bacterial pathogen capable of causing a wide range of disease manifestations, including severe bacterial pneumonia. Recently, clinics have reported a rise in nosocomial infections with multidrug resistant (MDR) species, including MDR strains of P. aeruginosa. In order to quickly evaluate the efficacy of new therapeutics for MDR infections, highly reproducible […]

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Cecal Ligation and Puncture-Induced Murine Sepsis Does Not Cause Lung Injury

Objective: The cause of death in murine models of sepsis remains unclear. The primary purpose of this study was to determine if significant lung injury develops in mice predicted to die after cecal ligation and puncture-induced sepsis compared with those predicted to live. Design: Prospective, laboratory controlled experiments. Setting: University research laboratory. Subjects: Adult, female, […]

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Dectin immunoadhesins and Pneumocystis pneumonia

… Blood oxygen saturation was 234 measured using a MouseOx pulse oximeter with a tail sensor (Starr Life 235 Sciences, Oakmont, PA). … ketamine, the tail sensor was placed at the base of the tail and measurements 237 were recorded using MouseOx software. … The opportunistic pathogen Pneumocystis jirovecii is a significant cause of disease […]

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Methods for Evaluation of Antiviral Efficacy Against Influenza Virus Infections in Animal Models

… see Note 5). 2.5 Special Equipment (Optional). 1. Pulse oximeter for measuring arterial oxygen saturation in mice, such as one specifically designed for mice, MouseOx Plus (Starr Life Sciences Corp., Oakmont, PA). 2. Whole … Compounds undergoing preclinical development for anti-influenza virus activity require evaluation in small animal models. Laboratory mice are most commonly […]

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Viral acute lower respiratory infections impair CD8+ T cells through PD-1

Viruses are leading causes of severe acute lower respiratory infections (LRIs). These infections evoke incomplete immunity, as individuals can be repeatedly reinfected throughout life. We report that acute viral LRI causes rapid pulmonary CD8+ cytotoxic T lymphocyte (TCD8) functional impairment via programmed death–1/programmed death ligand–1 (PD-1/PD-L1) signaling, a pathway previously associated with prolonged antigenic stimulation […]

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