Sleep Apnea & Other Chronic Respiratory Disorders

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deacetylase, is reduced in lungs of patients with COPD. However, the molecular signals underlying the premature aging in lungs, and whether SIRT1 protects against cellular senescence and various pathophysiological alterations in emphysema, remain unknown. […]

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Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry

Abstract Pulse oximetry is a common tool for detecting reduced pulmonary function in human interstitial lung diseases. It has not previously been used in a mouse model of interstitial lung disease. Further, platelet endothelial cell adhesion molecule deficient mice rarely show symptoms until disease is advanced. Using blood oxygen saturation, different stages of disease could […]

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Blunted Hypoxic Pulmonary Vasoconstriction in Experimental Neonatal Chronic Lung Disease

Abstract Rationale: Neonatal chronic lung disease (CLD), caused by prolonged mechanical ventilation (MV) with O2-rich gas, is the most common cause of long-term hospitalization and recurrent respiratory illness in extremely premature infants. Recurrent episodes of hypoxemia and associated ventilator adjustments often lead to worsening CLD. The mechanism that causes these hypoxemic episodes is unknown. Hypoxic […]

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Breathing and sleep: measurement methods, genetic influences, and developmental impacts.

Abstract Sleep-disordered breathing comprises alterations in respiratory rate, rhythm, and depth that present during sleep and may or may not be recognizable in breathing during wakefulness. Primary disorders include repetitive apneas, near apneas (hypopneas), or reductions in overall ventilation during sleep (hypoventilation), all of which lead to reductions in pulmonary gas exchange resulting in arousals, […]

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