Vital Signs Monitoring During Surgery & Experiments Requiring Anesthesia

Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice

… Animals were temporarily anesthetized with 2% isofluorane from a precision vaporizer (Midmark, Versailles, OH) through a nose cone and oxygen saturation was measured in the thigh using a MouseOx oximeter (Starr Life Sciences, Oakmont, PA). … Under steady state conditions, erythropoiesis occurs in the bone marrow. However, in mice, stress or tissue hypoxia results […]

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Ketosis proportionately spares glucose utilization in brain

… Heart rate, respiratory rate (breaths/min), plethysmography, and oxygen saturation (%) were monitored (via hind leg sensor) and recorded throughout the experiment using a pulse oximeter system (MouseOx, Starr life sciences, Oakmont, PA, USA) (Table 1). To maintain breath … The brain is dependent on glucose as a primary energy substrate, but is capable of […]

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Radiation mitigating properties of the lignan component in flaxseed

… Prior to sacrifice, at 16 weeks post-XRT, pulse oximetry was performed, as previously described [20], on conscious mice (n=5/group) using a MouseOx non-invasive vital signs monitor (STARR Life Sciences Corp., Oakmont, PA). … Background: Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while […]

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Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease

… Heart rate and blood oxygen saturation level were recorded using a MouseOx system (STARR Life Science, Oakmont, PA, USA) and maintained within normal physiological ranges. Cerebral Metabolic Rate of Glucose Measurements. … Vascular pathology is a major feature of Alzheimer’s disease (AD) and other dementias. We recently showed that chronic administration of the target-of-rapamycin […]

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