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Life Science Research Publications


The relationship between cocaine self-administration and actigraphy-based measures of sleep in adult rhesus monkeys.

Abstract RATIONALE: Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE: This study examined the effect of cocaine self-administration on behavioral indices of sleep and alternatively the effect of sleep disruption on cocaine-maintained responding by […]

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Synchronized electrical stimulation of the rat medial forebrain bundle and perforant pathway generates an additive BOLD response in the nucleus accumbens and prefrontal cortex

… Heating was provided from the ventral side. The breathing rate, heart rate and oxygen saturation were monitored during the whole experiment using an MRI-compatible pulse oxymeter (MouseOx TM, Starr Life Sciences Corp. Pittsburgh PA, USA). … To study how a synchronized activation of two independent pathways affects the fMRI response in a common targeted […]

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Radiation mitigating properties of the lignan component in flaxseed

… Prior to sacrifice, at 16 weeks post-XRT, pulse oximetry was performed, as previously described [20], on conscious mice (n=5/group) using a MouseOx non-invasive vital signs monitor (STARR Life Sciences Corp., Oakmont, PA). … Background: Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while […]

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Ketosis proportionately spares glucose utilization in brain

… Heart rate, respiratory rate (breaths/min), plethysmography, and oxygen saturation (%) were monitored (via hind leg sensor) and recorded throughout the experiment using a pulse oximeter system (MouseOx, Starr life sciences, Oakmont, PA, USA) (Table 1). To maintain breath … The brain is dependent on glucose as a primary energy substrate, but is capable of […]

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Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice

… Animals were temporarily anesthetized with 2% isofluorane from a precision vaporizer (Midmark, Versailles, OH) through a nose cone and oxygen saturation was measured in the thigh using a MouseOx oximeter (Starr Life Sciences, Oakmont, PA). … Under steady state conditions, erythropoiesis occurs in the bone marrow. However, in mice, stress or tissue hypoxia results […]

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