Abstract Background: The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88) is proinflammatory and plays a critical role in host immune response to invading pathogen and noninfectious tissue injury. The role of […]
Respiratory diseases are a major cause of mortality and morbidity worldwide. Current treatments offer no prospect of cure or disease reversal. Transplantation of pulmonary progenitor cells derived from human embryonic stem cells (hESCs) may provide a novel approach to regenerate endogenous lung cells destroyed by injury and disease. Here, we examine the therapeutic potential of […]
Arterial oxygen saturation has not been assessed sequentially in conscious mice as a direct consequence of an in vivo murine model of acute lung injury. Here, we report daily changes in arterial oxygen saturation and other cardiopulmonary parameters by using infrared pulse oximetry following intratracheal lipopolysaccharide (IT-LPS) for up to 9?days, and following IT-phosphate buffered […]
… system. Heart rate (HR) and oxygen saturation (SpO 2 ) were monitored via an animal pulse oximeter (MouseOx™, STARR Life Sciences Corporation™, Oakmont, PA, USA) by placing a non-invasive sensor on the tail. Peak … Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, holds promise as a diagnostic and prognostic plasma biomarker […]
… Page 7 of 32 John Wiley & Sons, Inc. Muscle & Nerve Page 8. saturation were monitored continuously with the MouseOX Plus (Starr LifeSciences Corp., Oakmont, PA) via a sensor placed on a shaved leg. Heart rate was maintained at 320 ± 20 beats per minute. … Introduction: Mechanical ventilation (MV) is a life-saving […]
… Evaluation of Cardiopulmonary Function Parameters Prior to sacrifice, at 16 weeks after irradiation, pulse oximetry was performed on conscious mice (n = 5/group) using a MouseOx noninvasive vital signs monitor (STARR Life Sciences Corp., Oakmont, PA). … While dietary wholegrain Flaxseed (FS) has potent anti-inflammatory, anti-fibrotic and antioxidant properties in murine models of acute […]
