Life Science Research Publications


A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice

… NY, USA). The hair of the right thigh was clipped and a pulse oximeter (MouseOx®, Starr Life Sciences Corp., Oakmont, PA, USA) probe was placed to monitor pulse rate (PR) and arterial haemoglobin saturation (SpO2). In addition … Background: Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, […]

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Stimulus-Evoked Calcium Transients in Somatosensory Cortex Are Temporarily Inhibited by a Nearby Microhemorrhage

… and imaging animals breathed oxygen-enriched air, body temperature was maintained at 37.5°C by a thermostatically regulated heating pad (Harvard Apparatus, Inc.), the blood oxygen saturation and heart rate were monitored using a pulse oximeter (MouseOx, Starr Life … Although microhemorrhages are common in the brain of the elderly, the direct impact of these lesions […]

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Cecal Ligation and Puncture-Induced Murine Sepsis Does Not Cause Lung Injury

Objective: The cause of death in murine models of sepsis remains unclear. The primary purpose of this study was to determine if significant lung injury develops in mice predicted to die after cecal ligation and puncture-induced sepsis compared with those predicted to live. Design: Prospective, laboratory controlled experiments. Setting: University research laboratory. Subjects: Adult, female, […]

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Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

… sec of hypoxia). Pulse oximetry. Arterial oxygen saturation in conscious, unrestrained mice was measured using a mouse pulse oximeter (MouseOx, Starr Life Sciences). Blood measurements. Blood samples were obtained from the tail vein of mice using … Oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor (HIF) by a set of closely related prolyl hydroxylase domain enzymes […]

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Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis

… Prior to the start of image acquisition, animal respiratory and heart rates were monitored using a pulseoximeter (MouseOx system, Starr Life Sciences Corp), and anesthesia adjusted to ensure similar physiological conditions between animals and across experiments. … Tumor-associated lymphatics are postulated to provide a transit route for disseminating metastatic cells. This notion is supported […]

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Interleaved imaging of cerebral hemodynamics and blood flow index to monitor ischemic stroke and treatment in rat by volumetric diffuse optical tomography

… was monitored by a rectal probe and was maintained by a heating pad between 36.5 0 C and 37 0 C. Physiological parameters including heart rate, breath rate, and arterial oxygen saturation were measured and monitored by a pulse oximeter (MouseOx, STARR Life Sciences … Diffuse optical tomography (DOT) has been used by several […]

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