Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour

… Body temperature was maintained using an infrared heat lamp and monitored with a rectal thermometer, and vital signs were monitored using a MouseOx pulse oximeter (STARR Lifesciences, USA). 2.4. Sample delivery. Owing … Particles suspended in the air are inhaled during normal respiration and unless cleared by airway defences, such as the mucociliary transit […]

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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) […]

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Pulmonary Gammaherpesvirus Infection and Pneumonitis Development Following Murine Bone Marrow Transplant.

Pulmonary complications are frequent following hematopoietic stem cell transplantation, including infections and pneumonitis. We have used a murine bone marrow transplant (BMT) model and murine gammaherpesvirus, γHV-68, to study alterations in anti-viral immunity post-transplant. When challenged with γHV-68, BMT mice have reduced ability to control lytic viral replication in the lung, despite immune reconstitution. By […]

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