Stroke & Brain Injury

Increased intracranial pressure after diffuse traumatic brain injury exacerbates neuronal somatic membrane poration but not axonal injury: evidence for primary intracranial pressure-induced neuronal perturbation

.. measurements. The ICP was measured intraventricularly as described above. Heart rate, respiratory rate, and blood oxygenation were monitored via a foot pulse oximetry sensor (STARR Life Sciences, Oakmont, PA, USA). A … Increased intracranial pressure (ICP) associated with traumatic brain injury (TBI) is linked to increased morbidity. Although our understanding of the pathobiology of […]

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Traumatic Brain Injury Increased IGF-1B mRNA and Altered IGF-1 Exon 5 and Promoter Region Epigenetic Characteristics in the Rat Pup Hippocampus

Abstract Traumatic brain injury (TBI) is a major cause of acquired cognitive disability in childhood. Such disability may be blunted by enhancing the brain’s endogenous neuroprotective response. An important endogenous neuroprotective response is the insulin-like growth factor-1 (IGF-1) mRNA variant, IGF-1B. IGF-1B mRNA, characterized by exon 5 inclusion, encodes the IGF-1 and Eb peptides. IGF-1A […]

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Persistent astroglial swelling accompanies rapid reversible dendritic injury during stroke-induced spreading depolarizations

… 2009, 2010, 2011). Mice were anesthetized with an intraperitoneal injection of urethane (1.5 mg/g body weight) with heart rate monitored (450–650 beats/min) using MouseOx® pulse oximeter (STARR Life Sciences). Depth of … Spreading depolarizations are a key event in the pathophysiology of stroke, resulting in rapid dendritic beading, which represents acute damage to synaptic […]

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MT5-MMP, ADAM-10, and N-Cadherin Act in Concert To Facilitate Synapse Reorganization after Traumatic Brain Injury

Abstract Matrix metalloproteinases (MMPs) influence synaptic recovery following traumatic brain injury (TBI). Membrane type 5-matrix metalloproteinase (MT5-MMP) and a distintegrin and metalloproteinase-10 (ADAM-10) are membrane-bound MMPs that cleave N-cadherin, a protein critical to synapse stabilization. This study examined protein and mRNA expression of MT5-MMP, ADAM-10, and N-cadherin after TBI, contrasting adaptive and maladaptive synaptogenesis. The […]

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Distinctive Effects of T Cell Subsets in Neuronal Injury Induced by Cocultured Splenocytes In Vitro and by In Vivo Stroke in Mice

.. 17 Rectal temperature was maintained at 37±0.5°C with a heating pad (Harvard Apparatus, Holliston, MA). Heart rate, oxygen saturation, and respiratory rate were monitored continuously (STARR Life Sciences Corp, Allison Park, PA). … Background and Purpose—T cells and their subsets modulate ischemic brain injury. We studied the effects of the absence of T cell […]

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Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

Objective—Recently, a growing number of studies have revealed a prothrombotic and cytotoxic role for extracellular chromatin. Cerebral ischemia/reperfusion injury is characterized by a significant amount of cell death and neutrophil activation, both of which may result in the release of chromatin. The goal of this study was to assess the effect of extracellular chromatin in […]

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